![]() Removal of the ACTH-producing source allows for curing or a significant reduction of symptoms and serum cortisol levels. It plays a pivotal role to extract the group of EAS patients from all CS patients due to a different management. The first time when EAS was named and largely studied was in the early 1960s by Liddle and soon after by Meador. Įctopic Cushing Syndrome (EAS) is a rare condition, responsible for about 5–20% of all (CS) cases and ca. ![]() Adenoma of the pituitary gland producing ACTH-Cushing disease (CD) is the most common source of endogenous hypercortisolemia, which accounts for about 60–70% of all CS cases whereas less common are adenomas of the suprarenal gland-a condition known as ACTH-independent CS (10–20% of all CS patients). As regards endogenous causes, they are divided into two groups: adrenocorticotropic hormone (ACTH)-dependent and ACTH-independent CS, responsible for about 70–80% and 20–30% of cases respectively. In most cases the source of CS lies in the excessive administration of glucocorticoids for various medical reasons. Hypercortisolemia and a set of symptoms caused by it is defined as Cushing Syndrome (CS).
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